Aug 16, 2018 epithelialmyoepithelial carcinoma is a relatively uncommon malignant neoplasm. Dec 01, 2018 what are the risk factors for myoepithelial carcinoma. Myoepithelial carcinoma malignant myoepithelioma of the breast is a rare tumor, for which only a limited number of reports have been published. Dedifferentiation of oncocytic epithelialmyoepithelial. Epithelial myoepithelial carcinoma emc, a very rarely seen, lowgrade, malignant, salivary gland tumor is most commonly located in the parotid gland followed by the submandibular gland.
Oncocytic and apocrine emca are uncommon variants that constitute up to 8 % of all emca. Epithelialmyoepithelial carcinoma emc is regarded as a rare lowgrade malignant tumor of the. Epithelialmyoepithelial carcinomaof salivary glands journal of. Epithelial myoepithelial carcinoma emca is a rare malignant tumour that typically arises in a salivary gland and consists of both an epithelial and myoepithelial component. Basal cell carcinoma with myoepithelial differentiation is a rare tumor. They are preponderantly tumors of the parotid glands with a relatively low mortality but a decided lo. Epithelial myoepithelial carcinoma emc is a lowgrade malignant salivary gland neoplasm accounting for 0. It is more often observed in females and in the 6 th decade of life. However, epithelial myoepithelial carcinoma with highgrade transformation emc with hgt is extremely rare, therefore it is easily to be inappropriately diagnosed and. Epithelialmyoepithelial carcinoma emc is a rare malignant neoplasm of the salivary gland, accounting for 0. A few cases of epithelial myoepithelial carcinoma arising in the nasal cavity have been reported. They are predominantly found in the parotid gland and represent approximately 1% of salivary gland tumo.
Click on the link to view a sample search on this topic. Factors significantly affecting diseasefree survival were positive margins, lymphovascular invasion, necrosis, and myoepithelial. Rare, low grade tumor with epithelial and myoepithelial components and frequent local recurrence also called glycogen rich adenoma clear cell pattern, myoepithelioma spindle cell and plasmacytoid patterns, myoepithelial carcinoma if only myoepithelial differentiation and marked cytologic atypia. Basal cell carcinoma with myoepithelial differentiation. Epithelialmyoepithelial carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing. The pathological diagnosis was epithelial myoepithelial carcinoma, as immunohistochemical analysis revealed that the inner cells stained positive for cytokeratin 7, an epithelial cell marker, whereas the outer cells stained positive for smooth muscle actin and p63, consistent with a myoepithelial phenotype. Epithelial myoepithelial carcinoma, with a biphasic pattern of ducts lined with inner and outer layers of epithelial and myoepithelial cells, may contain prominent foci of clear myoepithelial cells without the inner ductal layer.
Introduction epithelial myoepithelial carcinoma emc is defined by the world health organization who classification in 1991 as a rare lowgrade malignant neoplasm and account for than 1% of salivary glands tumors 1,2. What is the prognosis of epithelialmyoepithelial carcinoma of salivary gland. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer. Pdf epithelialmyoepithelial carcinoma emc is a lowgrade malignant tumor of the salivary glands. Pdf epithelial myoepithelial carcinoma of the parotid gland. It is considered to be a lowgrade malignant neoplasm. Epithelial myoepithelial carcinoma is a rare neoplasm that usually arises from the salivary glands, comprising approximately 1% of all salivary gland tumours 1, 2. Should not be confused with myoepithelial carcinoma.
Histologically, all the tumours were composed of small ducts with a double cell lining surrounded by a basement membrane. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Epithelial myoepithelial carcinoma is an uncommon, lowgrade carcinoma that generally occurs in the salivary glands. We report our experience with the guided nerve regeneration of the lingual nerve. Outcomesresolutions the prognosis of epithelialmyoepithelial carcinoma of salivary gland is generally better with early diagnosis and prompt treatment, rather than a late diagnosis and delayed treatment. Epithelialmyoepithelial carcinoma emc is a rare biphasic tumor of the. Epithelialmyoepithelial carcinoma of lung radiology. Epithelial myoepithelial carcinomas comprise approximately 1 % of all salivary gland neoplasms.
Epithelialmyoepithelial carcinoma of salivary gland. Epithelialmyoepithelial carcinoma emc, on the other hand, is a tumour with biphasic histology. They are most commonly seen in the parotid gland in approximately 60% cases but can also involve minor salivary glands of larynx, palate, paranasal sinuses, and lower respiratory tract. Four cases of epithelial myoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. Epithelial myoepithelial carcinoma of lung is a very rare type of lung carcinomas of the salivary gland type pathology. Epithelialmyoepithelial carcinoma of salivary glands. It comprises approximately 1 to 2% of salivary gland neoplasms. Pathology outlines epithelial myoepithelial carcinoma. Epithelialmyoepithelial carcinoma with highgrade transformation of. Epithelial myoepithelial carcinoma of the parotid gland. In the case of wound healing, myoepithelial cells reactively proliferate.
Dysphagia clinic, brief article by ear, nose and throat journal. Epithelial myoepithelial carcinoma emca is a rare salivary gland malignancy that comprises about 12 % of all salivary gland tumors and 25 % of malignant salivary gland tumors. Pulmonary epithelialmyoepithelial carcinoma pemc is a rare subset of salivary glandtype tumors of the lung. Epithelial myoepithelial carcinoma emc is regarded as a rare lowgrade malignant tumor of the salivary gland, accounting for 0. Epithelial myoepithelial carcinoma emca is a salivary tumor with dual. Epithelialmyoepithelial carcinoma of the base of tongue with.
Thetumorhasadistinctivehistopathologic pattern with a proliferation of. Epithelialmyoepithelial carcinoma of the parotid gland. The surgical margin was tumor free, and no recurrence has been observed for. It is important to note that having a risk factor does not mean that one will get the condition. Health, general candidiasis care and treatment esophageal diseases. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Dec 27, 2019 the median progression free survival for firstline chemotherapy was 9. Diagnosis is based on the identification of myoepithelial cells, with spindle cells, clear cells, or plasmacytoid differentiation or a mixture of phenotypes, along with a variable abundance of ductforming epithelium. Epithelial myoepithelial carcinoma emc is a rare biphasic tumor accounting for less than 2% of all salivary gland malignancies. The chart showing pdf series, word series, html series, scan qr codes.
A 71yearold man with a basal cell carcinoma with myoepithelial differentiation that presented as an asymptomatic red papule of two months duration on his forehead is described. Pdf epithelialmyoepithelial carcinoma of the parotid gland. Four cases of myoepithelial carcinoma with cytology were retrieved from the archives of the pathology departments of two academic institutes. Epithelialmyoepithelial carcinoma of parotid gland a. The histology of the tumor shows a biphasic pattern with clear myoepithelial cells encasing ducts with an epithelial lining. Conventional chemotherapy demonstrated some activity in myoepithelial carcinoma, however, more effective systemic therapies are required and enrolment in clinical trial should be encouraged.
Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or. Get a printable copy pdf file of the complete article 1. Epithelial myoepithelial carcinoma is a rare malignant tumor that ismore commonly encountered in salivary glands and comprises 1% of all salivarygland tumors. Diagnostic significance of hras mutations in epithelialmyoe. Epithelialmyoepithelial carcinoma emc is a rare, lowgrade, malignant. Cytology of myoepithelial carcinoma of the salivary gland. The 5year and 10year survival rates are 80% and 72% respectively. Unusual epithelialmyoepithelial carcinoma in palate case. Epithelialmyoepithelial carcinoma with highgrade transform. Primary epithelialmyoepithelial carcinoma of the lacrimal. Pulmonary epithelial myoepithelial carcinoma pemc is a rare subset of salivary glandtype tumors of the lung. Epithelial myoepithelial carcinoma, abbreviated emca, is a rare malignant salivary gland tumour. Epithelial cancer definition of epithelial cancer by. Epithelialmyoepithelial carcinoma emc and myoepithelial carcinoma mc are uncommon epit.
Mar 10, 2020 epithelial myoepithelial carcinoma is a cancer of the parotid salivary duct, with the most common occurrence in elderly people. Myoepithelial carcinoma and epithelialmyoepithelial. Eight and 18 months after parotidectomy, the patient had local recurrence of his salivary gland tumor. Diseasefree survival and other clinicopathologic parameters did not differ by the. Myoepithelial cells are specialized epithelial cells. Epithelialmyoepithelial carcinoma genetic and rare. Epithelial myoepithelial carcinoma of the nasopharynx.
Of all intrinsic lacrimal gland masses, 28% are epithelial neoplasms. Donath and coworkers are usually accredited with calling attention to this tumor in 1972. Emec tends to grow in a bulky lobulated fashion,withnecrosisandhyalinizationoflarge tumornodules. It is defined as a tumour composed of variable proportions of two cell types which typically form ductlike structures. The inner cells were epithelial and the outer cells myoepithelial, the latter usually. Epithelial myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. We report a 61yearold patient with breast myoepithelial carcinoma who developed locoregional and distant metastases and received many chemotherapy. Epithelial myoepithelial carcinoma is a relatively uncommon malignant neoplasm.
Other localized forms of epithelial carcinoma include acinar adenocarcinoma, which affects the prostate. Epithelialmyoepithelial carcinoma emc is a rare salivary gland tumor that is histologically chara. Four cases of epithelialmyoepithelial carcinoma of the salivary glands arose as. Sep 10, 2018 epithelial myoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Epithelial myoepithelial carcinoma emc is a relatively rare, lowgrade malignant tumor of the salivary gland. Epithelial myoepithelial carcinoma of the hard palate. Four cases of epithelialmyoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. We describe a unique case of aggressive epithelial myoepithelial carcinoma in the nasal cavity. Epithelialmyoepithelial carcinoma, abbreviated emca, is a rare malignant salivary gland tumour. Epithelialmyoepithelial carcinoma emc is less common and. Epithelialmyoepithelial carcinoma of salivary glands john. Epithelial myoepithelial carcinoma emca is a rare but well characterized biphasic salivary gland malignancy with several variant morphologies. Epithelial myoepithelial carcinoma frequent morphologic and molecular evidence of preexisting pleomorphic adenoma, common hras mutations in plag1intact and hmga2intact cases, and occasional tp53, fbxw7, and smarcb1 alterations in highgrade cases.
Myoepithelial carcinoma of the breast treated with surgery. Myoepithelial carcinoma frequently recurs after complete surgical resection. Epithelialmyoepithelial carcinoma lester dr thompson, md. Epithelialmyoepithelial carcinoma of the lung archives of. Epithelialmyoepithelial carcinoma affects children and adults and presents at a mean age of approximately 60 years. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. Oncocytic and apocrine epithelial myoepithelial carcinoma.
Epithelialmyoepithelial carcinoma of the parotid gland ncbi. Pubmed is a searchable database of medical literature and lists journal articles that discuss epithelial myoepithelial carcinoma. Basal cell carcinoma is the most common skin cancer. Epithelial myoepithelial carcinoma emc is a rare biphasic tumour of the salivary gland with two cell types of inner ductal cells and outer layer of clear cells. Misdiagnosis can occur on fnac as it can hit only one part of the tumor thus missing a malignant tumor or can interpret pleomorphic adenoma as epithelialmyoepithelial carcinoma. The median diseasefree survival was 80 months 95% confidence.
Notably, metastatic renal cell carcinoma is positive for both vimentin and cd10, but not s100 protein. It presents as a slowly growing, asymptomatic small size mass, with ulceration of overlying mucosa in some cases. Predisposing factors no clearly identified risk factors for myoepithelial carcinoma have been established to date. We report a case of epithelial myoepithelial carcinoma of bronchial gland origin in a 73yearold man who presented with coughing and dyspnea. Myoepithelial carcinoma, also know as malignant myoepithelioma, is rare in the salivary gland, and its cytologic features have rarely been reported. In the literature, there are only a few reports of emc originating from the hard palate. Primary epithelialmyoepithelial carcinoma of the lung. Since it was first described in 1972, there have only been 566 cases of epithelial myoepithelial carcinoma described in the literature. Myoepithelial carcinoma an overview sciencedirect topics. The relatively recently recognized and rarely encountered malignant myoepithelial tumor ie, myoepithelial carcinoma was first described by stromeyer et al 11 in 1975 and has been included in the world health organization classification of salivary gland tumors since 1991. Pdf epithelialmyoepithelial carcinoma emc is a rare biphasic tumor accounting for less than 2% of all salivary gland.